North Texas is well on its way to becoming one of the top startup hubs in the country, said Trey Bowles at The DEC’s annual State of Entrepreneurship event in early March. Over the past year, a number of announcements took place to bolster that idea—not the least of which were the region’s numerous launches, fundings, and exits, the DEC chairman says.

In terms of funding, Bowles said North Texas saw $2 billion invested in its entrepreneurs—a record high in the region.

DRC innovation and research chief Duane Dankesreiter presented a “lightning rundown” of the year in innovation at the event that’s billed as “the biggest night in North Texas entrepreneurship.”

“If you’re a startup, there are few better places to be than Dallas right now,” said Dankesreiter, pointing toward the density of corporate activity and growing population of the region that helps support both B2B and B2C startups.

Entrepreneurship isn’t possible without community education, government, and corporate leaders and partners who recognize and support startup innovation.

Here’s a look at the ecosystem in headlines.

The Dallas-Fort Worth Ecosystem

Pinnacle Group CEO Nina Vaca with Dallas Mayor Eric Johnson [Courtesy photo]

Dallas Mayor Names Pinnacle Group CEO Nina Vaca as Dallas’ First Entrepreneur-in-Residence

The city’s inaugural Entrepreneur-in-Residence position was recommended by the Mayor’s Task Force on Innovation and Entrepreneurship to better foster the start-up environment in Dallas. “While Dallas is known as a great place for big business, now we need to show that we are a great place for scalable, sustainable, and high-growth startups as well,” Vaca says.

UT Dallas’ Steve Guengerich said The IQ is “in many respects, the next-generation economic development engine for Richardson — really North Texas.” [City of Richardson video still]

Richardson’s Innovation Quarter — aka The IQ — Is Making Big Moves as a Living Lab and Nerve Center

With five new UT Dallas research centers, an extension of the university’s Venture Development Center, and new attractions like TheLab makerspace, The IQ may just realize Richardson’s vision to be “the premier tech hub in Texas.”

From left, SMU Cox Graduate Entrepreneurship Club leaders:
President Valecia Harris, VP of Entrepreneurship Community Outreach Matt Hauck, and VP of Fundraising/ Sponsorship Development Annabel Reeves.

SMU Announces All-New Business Accelerator to Support Next-Gen Entrepreneurs

Students and recent alumni of Southern Methodist University will have the opportunity to be a part of an “intense and enriching” 6-month program—and a chance to compete for funding.

[Rendering: Texas A&M University]

‘Aggieland North’: Texas A&M Plans New Research Campus in Downtown Fort Worth

Aggieland is headed to Fort Worth with what A&M’s chancellor calls a “Texas-sized commitment.” The proposed plan for the new urban campus includes the Texas A&M System Research and Innovation Center, the Education Alliance Building, and new law school.

Hector Rodriguez and Mike Rufail [Photo: Twitter]

OpTic Gaming Merges With Envy Gaming to Form a Combined North Texas Esports Powerhouse

The deal brings together Hector “HECZ” Rodriguez and Mike “Hastr0” Rufail—the leaders of OpTic and Envy, respectively—who have been longtime friends and esports rivals.

[Illustration: KrulUA/iStock]

LaunchBio Gets $750K From U.S. Department of Commerce’s $36.5M ‘Build to Scale’ Program

LaunchBio was one of 50 recipients of the program, which is led and managed by the Office of Innovation and Entrepreneurship at the U.S. Economic Development Administration, to accelerate technology entrepreneurship and fuel innovation. The nonprofit organization’s winning three-year proposal focuses on how to coordinate and enhance resources in North Texas to establish the region as a globally recognized entrepreneurial ecosystem. A large part of that is development of the Biotech+ Hub at Pegasus Park.

[Photos: MassChallenge]

MassChallenge Will Hold a Live Pitch Competition at Its Jan. 27 Pegasus Park Launch

At the free, live, in-person networking event, attendees will hear from the MassChallenge team and key partners about the North Texas launch. The live pitch competition will allow early-stage startups to compete for a direct spot in the MassChallenge 2022 Global Early-Stage Program.

Parkland’s SuperBetter app “takes the best of psychology and a seven-point methodology” to empower youth and other users to navigate life in a way to build resilience.

United Way of Metropolitan Dallas Awards $1M in Health Innovation Technology Prize Funding

Five local winners received up to $200,000 in funding to activate their solutions throughout North Texas.

[Photo: Courtesy AllianceTexas]

How AllianceTexas’ Mobility Innovation Zone is Defining the Future of Logistics (PROMOTED)

Grounded in the legacy of Hillwood, the MIZ is a nexus of innovation in surface and air mobility.

Photo: DragonImages/iStock

Safer Air, Safer Streets: North Texas Center for Mobility Technologies Announces First Two Fundings

The University of North Texas is partnering with two Dallas-area startups on breakthrough mobility solutions—with part of an estimated $600K in total funding provided by the NTCMT. One startup is developing an airspace hazard identification and alerting service to ensure safe unmanned aircraft flights. The other is working on object detection technology to keep bicyclists safe from vehicle collisions.

MLTPLY Founder and CEO Gloria Guntiñas [Photo: MLTPLY]

Dallas-based MLTPLY Launches to Help Insurtech Startups Get Off the Ground—Fast

The new investment and accelerator platform, which launched this week in North Texas, wants to help seed-stage companies “cut through red tape”— and get to market up to 18 months sooner than they would on their own.

Impact Ventures to Host a Spring Virtual Startup Showcase and $50K Pitch Competition

“Equity in Motion” will focus on bridging the wealth gap for minority entrepreneurs through a virtual “Shark Tank”-style showcase, expert-led breakout sessions, live virtual networking, and more.

DEC Network CEO Bill Chinn [Photo: Michael Samples]

The DEC Network Awarded $1M Grant from SBA’s Community Navigator Pilot Program

The American Rescue Act initiative aims to reduce barriers that underrepresented and underserved entrepreneurs often face in accessing the programs they need to recover, grow, or start their businesses. The Dallas Entrepreneur Center will use the grant to engage efforts with six Dallas-area organizations: Veteran Women’s Enterprise Center; LiftFund; TruFund; Dallas College; BCL of Texas; and WiNGS.

Aiotics founder Maruthi Karpey [Photo: Linkedin]

AI Startup Aiotics Opens Its Headquarters With a Grant From the McKinney EDC

The young startup, which makes scalable artificial intelligence solutions, is using a grant from the McKinney Economic Development Corporation’s Innovation Fund to establish a headquarters in McKinney and drastically add to its team.

Techstars Seeks Physical Therapy-Focused Startups for Its First North Texas Cohort in Fort Worth

Applications opened to startups everywhere in February 2022.

Jorge Varela

New Dallas Regional Chamber VP of Innovation: ‘We’re only getting stronger’

Jorge Varela has spent decades building startups in Silicon Valley, San Antonio, and even in Central America—his place of origin. Now his efforts will center on North Texas’ innovation economy. “The shift from Silicon Valley and the East Coast to Texas and DFW is real,” Varela says.

Startup Stories of the Year

Joe Beard and Joel Radtke [Photo: CollateralEdge]

‘The Next Fintech Unicorn’: Dallas-Based CollateralEdge Emerges From Stealth With $3.5M and a Stellar Investor Group

VC-turned-entrepreneur Joe Beard and financier Joel Radtke co-founded the new fintech to solve a “massive problem” in middle-market lending. CollateralEdge aims to help community and regional banks overcome collateral shortfalls, improve credit risk management, and drive profitable, long-term customer relationships. Capital partners include VC firm Perot Jain, Capital Factory CEO Josh Baer, and Kneeland Youngblood, the founding partner of Pharos Capital Group.

Island founders Mike Fey and Dan Amiga have introduced the “first enterprise browser to radically improve enterprsie security” —and redince the nature of work. [Photo: MKJ Photography/Islands]

Dallas-Based Island Emerges from Stealth with Nearly $100M in funding, 100+ Employees

Island, an enterprise browser platform company, has landed nearly $100 million in funding from early-stage investors Insight Partners, Sequoia Capital, Cyberstarts, and Stripes. Its goal: to be “where today’s hybrid workforce lives.”

Rendering of Von Perry’s concrete 3D-printed home being built in Nevada, Texas. [Image: Von Perry]

Dallas Startup Von Perry Is Building a 3D-Printed Home in Collin County

Von Perry’s 21-year-old CEO, Treyvon Perry, has been preparing for this since he founded the startup at age 17. He and his co-founder, 27-year-old CTO Sebin Joseph, are pioneering a new way to build concrete 3D-printed homes using regular concrete—and aim to prove the concept for DFW and beyond.

[Image: Zabo]

Dallas Cryptocurrency Startup Zabo Acquired by Coinbase

Zabo offers integrations with most top exchanges and wallets. The company, founded in 2018, is a good fit with Coinbase, which has worked to bring cryptocurrency mainstream, particularly with its IPO in April 2021.

Nanoscope Therapeutics’ Anthony Togba, Samarendra Mohanty, and Sulagna Bhattacharya [Photos: Nanoscope Therapeutics]

Bedford Biotech Restores “Meaningful Vision” in Blind Patients With Gene Therapy—and May Soon Go Public

Nanoscope Therapeutics successfully treated 11 patients blinded by advanced retinitis pigmentosa (RP). A single intravitreal injection produced positive results that persisted through one year. The startup plans a Phase 2b trial this summer and plans to develop gene therapies to treat more common retinal diseases—like dry age-related macular degeneration.

Mei Mei Hu, co-founder and CEO of Vaxxinity [Photo: Vaxxinity]

Dallas-Based Vaxxinity Prepares for $100M IPO; Aims to Turn Immune Systems Into ‘Antibody Factories’

Vaxxinity’s COVID-19 vaccine candidate is “super safe and mild and doesn’t bring recipients down for a couple of days with flu-like symptoms,” says the company’s co-founder and CEO, Mei Mei Hu. Unlike mRNA vaccines from Modern and Pfizer, Vaxxinity says its protein peptide-based platform is based on tech that led to a vaccine for foot-and-mouth disease in livestock.

Dallas Health Solutions Startup MediBookr Acquired by Plano’s Catalyst Health Network

The parent company of Catalyst Health Network, StratiFi Health, has acquired MediBookr, which streamlines communication between patients and providers with its digital suite of solutions. Catalyst Health Network and MediBookr will now act as one organization dedicated to enabling primary care for everyone.

[Photo: Alto]

Dallas Rideshare Alto Closes $45M Series B, Bringing Total Funding to $60M

When Alto initially joined the ride-hailing industry in 2018, it wanted to take a different approach by hiring its drivers as W-2 employees and operating its own branded, luxury vehicles. With the new capital, the local startup plans to continue innovating by transitioning to a 100 percent electric fleet by the end of 2023.

[Photo: Courtesy Hedera]

Hedera Hashgraph Eyes ‘Next‑Generation Gaming’ with Ubisoft Partnership

The HBAR Foundation, an independent organization funded and established by the Richardson-based distributed ledger technology company, is partnering with French videogame developer Ubisoft in an effort to support gaming and entertainment innovators worldwide.

Photos: CASPR Group

Fresh Air: CASPR Group’s Disinfection Tech Can Kill Up to 99.99% of COVID-Causing Virus in 24 Hours

Through the Addison-based company’s continuous air and surface disinfection products, bacteria, viruses, molds, and more can be eliminated indoors. This includes the SARS-CoV-2 virus. Now, the CASPR team wants the public to know they’re here to help: They offer a multitude of solutions that solve whatever challenge may be existing within an indoor space. Leadership says it’s “a very well kept secret,”—but they “don’t want it to be to be a secret.”

Center: Monique Little, founder of You Go Natural [Photos: You Go Natural]

Dallas-Based Hair and Beauty Company You Go Natural Raises $2 Million in Seed Funding Round

Capital Factory and Brand Foundry Venture Partners are among You Go Natural’s investors. The startup produces headwraps, headbands, and turbans to help make hair care both functional and beautiful. “We are building the go-to source for innovation in natural beauty,” Founder Monique Little told us. She was named to the inaugural Forbes Next 1000 list earlier this year.

Veryable CEO and Co-Founder Mike Kinder. [Image: Michael Samples/Dallas Innovates]

Veryable Raises $31.9M Series A Round to ‘Revitalize U.S. Manufacturing’

Veryable takes a new approach to labor: The Dallas-based tech company “variablizes” it. By connecting businesses to independent workers for manufacturing and distribution, Veryable’s operations-driven approach can put people back to work and improve productivity and growth for manufacturers and suppliers.

Mark Cuban Cost Plus Drug Company Dallas Deep Ellum

Mark Cuban, co-founder of the Mark Cuban Cost Plus Drug Company. [Photo: MCCPDC]

Mark Cuban Launches His Online Cost-Plus Pharmacy, Takes on Big Pharma with Low‑Cost Generics

The Mark Cuban Cost Plus Drug Company aims to “disrupt and disable big pharma” by offering more than 100 generic drugs “at striking savings” direct to consumers on a cash-pay basis. As a pharmaceutical wholesaler, MCCPDC says it can “bypass middlemen and outrageous markups” by simply charging a flat 15% margin and pharmacist fee. With an $11M plant going up now in Deep Ellum, Cuban clearly means business.

Dennis Cail, co-founder and CEO of Zirtue

Dallas Fintech Zirtue Receives Investment From Northwestern Mutual, Bringing Its Total Seed Funding to $4M

The VC arm of Northwestern Mutual, Northwestern Mutual Future Ventures, invests in financial technology startups that are focused on historically underbanked and underfunded populations. That’s Zirtue’s bread and butter: The growing startup touts the first and only relationship-based lending app that drives financial inclusion and freedom.