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UTSW
In this image, the proteasome—a cell’s protein disposal system—is shown in tan and grey. A protein called midnolin (in red) connects with two key parts of the proteasome, RPN1 (blue) and RPN11 (green), to help deliver damaged or unwanted proteins for breakdown. This interaction helps keep cells healthy by clearing out the cellular junk. [Image: UTSW]
UT Southwestern Maps a Cancer-Enabling Protein That Lets B-Cell Tumors Hang On—With a Nobel Laureate on the Case
by Lance Murray | Jun 16, 2025
The protein—implicated in blood cancers like leukemia, lymphoma, and multiple myeloma—was decoded in near-atomic detail by UT Southwestern researchers, including Nobel Prize winner Bruce Beutler. In lab models, turning off midnolin wiped out up to 92% of cancer cells—with minimal impact on healthy ones, according to UT Southwestern.
by David Seeley |
Aug 6, 2024
A study co-led by UTSW's Jin Huk Choi, Ph.D., and Nobel Prize winner Bruce Beutler, M.D., found that targeting a gene-produced protein called ZFP574 "reduced the amount of malignant B cells by as much as 92%." Their findings could lead to new treatments for leukemias and lymphomas—and potentially other cancers, too.
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by Lance Murray |
Jun 17, 2024
Researchers at Children's Hospital of Philadelphia and UT Southwestern analyzed T-cell receptors in nearly 500 blood samples from pre-diagnostic patients with ovarian cancer. The results point to the potential of testing for biomarkers 2 to 4 years before most cases of HGOC are currently diagnosed.
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by Quincy Preston |
Dec 30, 2022
As one of the nation’s premier academic medical centers, nurturing employees for management and leadership roles is mission critical. The medical center, with its workforce of nearly 23,000, received the 2022 BOLD award for its leadership development.
“As we do with our scientific, medical, and training missions, we apply data-driven strategies to nurture leaders who contribute to our institution’s culture of integrity, inclusiveness, and collaboration, and extend those qualities throughout the organization,” Holly Crawford said.
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Philipp Scherer, associate director of UT Southwestern's Nutrition Obesity Research Center, delivers a President's Lecture Series exploration of obesity. [Photo: UTSW]
UT Southwestern Is Selected as One of 12 NIH Obesity Research Centers
by Lance Murray | Sep 28, 2022
Over 150 scientists across dozens of departments will be part of the elite National Institutes of Health-funded, university-wide interdisciplinary research center. Dallas' UT Southwestern Medical Center is the only institution in Texas to be selected for the NIH initiative.
UTSW wants to translate scientific discoveries into new therapeutic strategies for the prevention and treatment of obesity, which it describes as a chronic disease affecting more than 40% of the U.S. population, with medical costs nearing $175 billion.
UTSW wants to translate scientific discoveries into new therapeutic strategies for the prevention and treatment of obesity, which it describes as a chronic disease affecting more than 40% of the U.S. population, with medical costs nearing $175 billion.
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by Dallas Innovates | Staff Report |
Sep 12, 2022
From obesity to cardiovascular disease, we live in an era of unprecedented diet-related health problems. But Dr. Albin, who leads the Culinary Medicine program at UT Southwestern, and her team are trying to cook up a solution by reviewing programs at medical schools across the U.S.
The review of programs by UT Southwestern researchers has been published in Academic Medicine, the journal of the Association of American Medical Colleges.
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by Alex Edwards |
Nov 15, 2021
The $120 million Texas Instruments Biomedical Engineering and Sciences Building, supported by a gift from Dallas-based Texas Instruments, will focus on advancing transformational bioengineering research that can find solutions to unmet medical needs. It's set to open in 2023.
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by Quincy Preston |
May 13, 2021
Scientist Chen Liu and his colleagues published new findings that suggest a way to counteract the extra weight that can lead patients to stop taking their medication. Possibilities include a recently FDA-approved drug to treat genetic obesity.
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Sean Morrison, the director of CRI, and Bo Shen, a postdoctoral fellow for CRI [Photo: UT Southwestern]
UTSW’s Children’s Medical Research Institute Discovers Why Exercise Helps Build New Bones and Improve Immune Function
by Alexa Vickaryous | Feb 24, 2021
The scientist's research indicates that exercise can reverse thin bones caused by old age, highlighting the importance of older patients staying active.
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by Alex Edwards |
Feb 3, 2021
The program will offer eight Dallas biotech and life science companies free business training with the hope that they will one day locate their companies to Pegasus Park, a mixed-use social purpose project near the Dallas Design District and the Southwestern Medical District.
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by Alex Edwards |
Jan 13, 2021
The expanded alliance between Taysha and UTSW, which dates back to when Taysha emerged from stealth in April 2020, will support the discovery of novel gene therapy candidates and technologies in new disease areas.
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![This year’s winners from UT Southwestern —Olutoyosi “Toy” Ogunkua, M.D., Luis Sifuentes-Dominguez, M.D, and Chika Nwachukwu, M.D., Ph.D.—bring the total number grants awarded by the Council since its founding five years ago to nine. [Images via UTSW]](https://s24806.pcdn.co/wp-content/uploads/2021/01/UTSW-investigators-360x203.jpg)
by Alex Edwards |
Jan 11, 2021
Members raised nearly $100K in funding for the research awardees who will investigate new evidence-based pathways that can treat some of the world’s most intractable illnesses.
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[Image: Oleksandr Bushko/istockphoto]
UTSW Scientist: ‘We Need More Women Thinking Creatively in the Lab and Pushing Science Forward’
by Quincy Preston | Oct 8, 2020
This year's Nobel Prize in Chemistry, awarded to two female scientists for the development of CRISPR as a gene-editing tool, is a revolution, according to a pair of UTSW scientists.
UTSW's Eric Olson and Rhonda Bassel-Duby use the technology in their work to treat Duchenne muscular dystrophy. Olson also is the co-founder of biotech Exonics Therapeutics, which exited last year in a deal roughly valued at $1B.
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by Alex Edwards |
Oct 7, 2020
John Schoggins is one of 10 recipients for the National Institutes of Health's Pioneer Award. The forward-looking researcher is ahead of the curve, beginning the pursuit prior to the current pandemic.
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by Alex Edwards |
Sep 24, 2020
Using alternating magnetic fields in technology created by UTSW researchers, Solenic Medical aims to provide a better way to treat prosthetic joint infections than the current standard of care. Recently, the startup received an FDA designation of a Breakthrough Device.
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by Dave Moore |
Aug 4, 2020
Virus researchers at UT Southwestern Medical Center have amped up their lab and data work to fight and defeat COVID-19. Here are key takeaways from UTSW's Claire Aldridge, who herself has battled the virus and fully recovered.
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