In this image, the proteasome—a cell’s protein disposal system—is shown in tan and grey. A protein called midnolin (in red) connects with two key parts of the proteasome, RPN1 (blue) and RPN11 (green), to help deliver damaged or unwanted proteins for breakdown. This interaction helps keep cells healthy by clearing out the cellular junk. [Image: UTSW]
A clinical trial led by researchers at UT Southwestern Medical Center in Dallas could help bring an experimental treatment for depression closer to approval from the U.S....